Search on: HISTONE H1 KINASE, M-PHASE-SPECIFIC 
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Descriptor English:   Maturation-Promoting Factor 
Descriptor Spanish:   Factor Promotor de Maduración 
Descriptor Portuguese:   Fator Promotor de Maturação 
Synonyms English:   Histone H1 Kinase, Growth-Associated
Histone H1 Kinase, Growth Associated
Histone H1 Kinase, M Phase Specific
M Phase Promoting Factor
Maturation Promoting Factor
Mitosis Promoting Factor
Histone H1 Kinase, M-Phase-Specific
M Phase-Promoting Factor
Mitosis-Promoting Factor  
Tree Number:   D08.811.913.696.620.682.700.646.500.984
D12.644.360.250.580
D12.776.167.200.580
D12.776.476.250.580
Definition English:   Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2. 
Indexing Annotation English:   DF: MPF
See Related English:   Cyclins
 
History Note English:   91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   29039 
Unique Identifier:   D016200 

Occurrence in VHL:
 

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